Alleviation Effects of Diosmetin on H2O2-Induced Oxidative Damage in Human Erythrocytes

Free radicals (FRs) are formed in the high amounts result of metabolic imbalance cells and tissue. These radicals-induced oxidative damages constitute basis many diseases. Organisms have antioxidant defence systems (ADS) to eliminate destructive effects damage. In addition these systems, dietary flavonoids effect protective role against present study, it was investigated whether a flavonoid derived diosmetin (10, 50, 100 µM) elimination potential on hydrogen peroxide (H2O2)-induced damage erythrocyte culture by using biomarkers such as lipid peroxidation (LP) level, catalase (CAT), total superoxide dismutase (SOD) activity changes SOD isozymes containing manganese (Mn SOD) cupper-zinc (CuZn SOD). CAT, SOD, Mn CuZn activities showed serious decline with H2O2 treatment, but significantly increased their activities. While application critically LP products erythrocytes, considerably reduced products. conclusion, has been determined that can moderate human erythrocytes activating or protecting ADS.